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Innate immune responses in RNA viral infection
Qian Xu, Yuting Tang, Gang Huang
《医学前沿(英文)》 2021年 第15卷 第3期 页码 333-346 doi: 10.1007/s11684-020-0776-7
关键词: innate immune viral infection intercellular signaling metabolic changes epigenetic changes
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 260-267 doi: 10.15302/J-FASE-2016116
关键词: antiviral blood brain barrier chemokines and cytokines innate immunity rabies virus
《医学前沿(英文)》 2022年 第16卷 第4期 页码 596-609 doi: 10.1007/s11684-021-0868-z
关键词: innate immune checkpoint Siglec10 kidney renal clear cell carcinoma
《医学前沿(英文)》 doi: 10.1007/s11684-023-1016-8
关键词: p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response
Tangchun Wu
《医学前沿(英文)》 2020年 第14卷 第6期 页码 816-819 doi: 10.1007/s11684-020-0823-4
免疫细胞在器官移植免疫排斥和免疫耐受中的不同作用 Review
干晓杰, 古鉴, 鞠峥, 吕凌
《工程(英文)》 2022年 第10卷 第3期 页码 44-56 doi: 10.1016/j.eng.2021.03.029
器官移植免疫排斥反应是由多种细胞参与的复杂的免疫应答过程,是决定移植成败和患者生存的关键因素。目前大多数器官移植患者采用免疫抑制剂和生物制剂的组合疗法来控制移植器官的免疫排斥反应,然而免疫抑制剂的使用会降低移植患者免疫系统功能,导致严重的并发症,如慢性感染、恶性肿瘤等。因
此,彻底了解器官移植免疫耐受和免疫排斥的相关机制对于开发更好的治疗方案和改善患者预后至关重要。本文对免疫细胞在器官移植免疫排斥和免疫耐受诱导过程中的作用,以及目前针对移植患者处于临床试验阶段的新型细胞治疗进行概述。
《医学前沿(英文)》 页码 878-888 doi: 10.1007/s11684-023-0993-y
关键词: uveal melanoma liver-directed therapy immune checkpoint blockade SIRT anti-PD-1 anti-CTLA-4
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 1-5 doi: 10.1007/s11684-014-0309-3
Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immune cells, including antigen-presenting cells, T cells, and natural killer cells. Heat shock temperature (41β°C to 43β°C) can increase the immunogenicity of tumor cells. Cytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia.
Jianpeng Liu, Xinhua Chen, Shusen Zheng
《医学前沿(英文)》 2021年 第15卷 第2期 页码 170-177 doi: 10.1007/s11684-020-0747-z
关键词: nanosecond pulsed electric fields (nsPEF) hepatocellular carcinoma (HCC) immune response recurrence metastasis
Integrated analysis of gut microbiome and host immune responses in COVID-19
《医学前沿(英文)》 2022年 第16卷 第2期 页码 263-275 doi: 10.1007/s11684-022-0921-6
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 471-479 doi: 10.1007/s11684-017-0602-z
Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutinin stalk domain are in development. Typically, these vaccines induce responses that target group 1 or group 2 hemagglutinins with little to no cross-group reactivity and protection. Similarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directed against group 1 or group 2 hemagglutinins with very few that bind to hemagglutinins of both groups. Here we review what is known about the human humoral immune response to vaccination and infection with H7 subtype influenza viruses on a polyclonal and monoclonal level. It seems that unlike vaccination with H5 hemagglutinin, which induces antibody responses mostly restricted to the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses. A better understanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus vaccine candidates.
关键词: universal influenza virus vaccine hemagglutinin stalk H7N9
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
《医学前沿(英文)》 2008年 第2卷 第1期 页码 95-99 doi: 10.1007/s11684-008-0017-y
关键词: development challenging rSj14-3-3 resistance cultural supernatant
Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine
Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 390-395 doi: 10.1007/s11684-009-0087-5
关键词: Epstein-Barr virus latent membrane protein 2 nasopharyngeal carcinoma humoral immunity
Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system
Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han
《医学前沿(英文)》 2020年 第14卷 第6期 页码 726-745 doi: 10.1007/s11684-020-0746-0
关键词: CAR T cells immunoregulatory molecules endogenous immune response solid malignancies
Toll-like receptors in innate immunity and infectious diseases
Min-Hao WU, Ping ZHANG, Xi HUANG,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 385-393 doi: 10.1007/s11684-010-0600-x
关键词: Toll-like receptors innate immunity infectious disease inflammation
标题 作者 时间 类型 操作
Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
期刊论文
Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient
期刊论文
Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical
期刊论文
Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges
Tangchun Wu
期刊论文
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint
期刊论文
Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected
null
期刊论文
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric
Jianpeng Liu, Xinhua Chen, Shusen Zheng
期刊论文
Universal influenza virus vaccines: what can we learn from the human immune response following exposure
null
期刊论文
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
期刊论文
Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine
Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,
期刊论文
Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system
Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han
期刊论文